Project acronym: BioCog

Project full title: "Biomarker Development for Postoperative
Cognitive Impairment in the Elderly"



Neuroimaging biomarkers

Neuroimaging is a window into the brain. It allows the study, with high sensitivity, of abnormal structure and function in specific brain circuits.
(click on the image to zoom)


arrow Structural magnetic resonance imaging (MRI)

arrow Arterial Spin Labeling (ASL)

arrow Simultaneous Electroencephalogram (EEG)/Functional magnetic resonance imaging (fMRI)

arrow Glutamate/GABA MR Spectroscopy (MRS)

arrow Gadolinium MRI

Molecular biomarkers

arrow Plasma biomarkers

arrow Validation of plasma markers

arrow Genetic biomarkers


Two major and complementary bioinformatics approaches will be pursued:

1) Integration of neuroimaging and molecular data to develop a multivariate expert system to predict POD/POCD.

2) Neural network models to aid understanding the complexity of the data.

arrow Expert system

arrow Neural networks